Given its isolation, it makes sense for the Appalachian area to have moonshine as a part of its history. As AppalachianTrailHistory.com notes, “[h]omemade liquor is frequently called ‘moonshine’ because it was commonly made at night, under the cover of darkness and by the light of the moon. This subterfuge helped to keep this illegal activity under wraps and away from the notice of law enforcement.”
Also, the site mentions that Appalachian residents are also Scots Irish. This is because their ancestors brought homebrewed whiskeys with the them to the new area, using the isolation of Appalachian.